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In mouse models of AP, NLRP3 deficiency ameliorated pancreatic inflammation and associated complications by reducing neutrophil infiltration ( 5 TCM used to relieve AP by targeting NLRP3 In Chinese medicine (CM), AP is classified under abdominal pain ( Futong ), spleen-heart pain ( Pi Xintong ), and pancreatic inflammation ( Yi Dan ) ( Gan Yu ), trauma, and invasion of exogenous pathogens ( Liu Yin ) ( Ben Xu ) with branch excess ( Biao Shi ), predominantly presenting as interior excess-heat syndrome ( Li Shi Re Zheng ) ( Qing Re Tong Fu Fa ), integrating root-cause treatment ( Zhi Ben ) with symptomatic management ( Zhi Biao ) (Zeng et al., 2024

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